Rare bacterial isolates causing bloodstream infections in Ethiopian patients with cancer
Identifieur interne : 001700 ( Main/Exploration ); précédent : 001699; suivant : 001701Rare bacterial isolates causing bloodstream infections in Ethiopian patients with cancer
Auteurs : Balew Arega [Éthiopie] ; Yimtubezinash Wolde-Amanuel [Éthiopie] ; Kelemework Adane [Éthiopie] ; Ezra Belay [Éthiopie] ; Abdulaziz Abubeker [Éthiopie] ; Daniel Asrat [Éthiopie]Source :
- Infectious Agents and Cancer [ 1750-9378 ] ; 2017.
Abstract
In recent years, saprophytic bacteria have been emerging as potential human pathogens causing life-threatening infections in patients with malignancies. However, evidence is lacking concerning such bacteria, particularly in sub-Saharan countries. This study was designed to determine the spectrum and drug resistance profile of the rare bacterial pathogens causing bloodstream infections (BSIs) in febrile cancer patients at a referral hospital in Ethiopia.
Between December 2011 and June 2012, blood samples were collected from 107 patients with cancer in Tikur Anbessa hospital. Culturing was performed using the blood culture bottles and solid media and the microorganisms were identified using the gram staining and APINE identification kits (Biomerieux, France). The disk diffusion method was used for the antimicrobial susceptibility testing.
Overall, 13 (12.2%) rare human pathogens were isolated from 107 adult febrile cancer patients investigated.
This study revealed the emergence of saprophytic bacteria as potential drug-resistant nosocomial pathogens in Ethiopian patients with cancer. As these pathogens are ubiquitous in the environment, infection prevention actions should be strengthened in the hospital and early diagnosis and treatment with appropriate antibiotics are warranted for those already infected.
Url:
DOI: 10.1186/s13027-017-0150-9
PubMed: 28702079
PubMed Central: 5504797
Affiliations:
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Box 9086, Addis Ababa, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Churchill Avenue, P.O. Box 9086, Addis Ababa</wicri:regionArea><wicri:noRegion>Addis Ababa</wicri:noRegion></affiliation></author><author><name sortKey="Wolde Amanuel, Yimtubezinash" sort="Wolde Amanuel, Yimtubezinash" uniqKey="Wolde Amanuel Y" first="Yimtubezinash" last="Wolde-Amanuel">Yimtubezinash Wolde-Amanuel</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1250 5688</institution-id><institution-id institution-id-type="GRID">grid.7123.7</institution-id><institution>Department of Microbiology,</institution><institution>Immunology & Parasitology, School of Medicine, College of Health Sciences, Addis Ababa University,</institution></institution-wrap>Churchill Avenue, P.O. Box 9086, Addis Ababa, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Churchill Avenue, P.O. 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Box 9086, Addis Ababa, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Churchill Avenue, P.O. Box 9086, Addis Ababa</wicri:regionArea><wicri:noRegion>Addis Ababa</wicri:noRegion></affiliation></author><author><name sortKey="Asrat, Daniel" sort="Asrat, Daniel" uniqKey="Asrat D" first="Daniel" last="Asrat">Daniel Asrat</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1250 5688</institution-id><institution-id institution-id-type="GRID">grid.7123.7</institution-id><institution>Department of Microbiology,</institution><institution>Immunology & Parasitology, School of Medicine, College of Health Sciences, Addis Ababa University,</institution></institution-wrap>Churchill Avenue, P.O. Box 9086, Addis Ababa, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Churchill Avenue, P.O. 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Box 9086, Addis Ababa, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Churchill Avenue, P.O. Box 9086, Addis Ababa</wicri:regionArea><wicri:noRegion>Addis Ababa</wicri:noRegion></affiliation></author><author><name sortKey="Wolde Amanuel, Yimtubezinash" sort="Wolde Amanuel, Yimtubezinash" uniqKey="Wolde Amanuel Y" first="Yimtubezinash" last="Wolde-Amanuel">Yimtubezinash Wolde-Amanuel</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1250 5688</institution-id><institution-id institution-id-type="GRID">grid.7123.7</institution-id><institution>Department of Microbiology,</institution><institution>Immunology & Parasitology, School of Medicine, College of Health Sciences, Addis Ababa University,</institution></institution-wrap>Churchill Avenue, P.O. Box 9086, Addis Ababa, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Churchill Avenue, P.O. Box 9086, Addis Ababa</wicri:regionArea><wicri:noRegion>Addis Ababa</wicri:noRegion></affiliation></author><author><name sortKey="Adane, Kelemework" sort="Adane, Kelemework" uniqKey="Adane K" first="Kelemework" last="Adane">Kelemework Adane</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1539 8988</institution-id><institution-id institution-id-type="GRID">grid.30820.39</institution-id><institution>Department of Microbiology and Immunology,</institution><institution>College of Health Sciences, Mekelle University,</institution></institution-wrap>P.O.Box 1872, Mekelle, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>P.O.Box 1872, Mekelle</wicri:regionArea><wicri:noRegion>Mekelle</wicri:noRegion></affiliation></author><author><name sortKey="Belay, Ezra" sort="Belay, Ezra" uniqKey="Belay E" first="Ezra" last="Belay">Ezra Belay</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1539 8988</institution-id><institution-id institution-id-type="GRID">grid.30820.39</institution-id><institution>Department Medical Biochemistry,</institution><institution>College of Health Sciences, Mekelle University,</institution></institution-wrap>P.O.Box 1872, Mekelle, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>P.O.Box 1872, Mekelle</wicri:regionArea><wicri:noRegion>Mekelle</wicri:noRegion></affiliation></author><author><name sortKey="Abubeker, Abdulaziz" sort="Abubeker, Abdulaziz" uniqKey="Abubeker A" first="Abdulaziz" last="Abubeker">Abdulaziz Abubeker</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1250 5688</institution-id><institution-id institution-id-type="GRID">grid.7123.7</institution-id><institution>Department of Internal Medicine,</institution><institution>School of Medicine, College of Health Sciences, Addis Ababa University,</institution></institution-wrap>Churchill Avenue, P.O. Box 9086, Addis Ababa, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Churchill Avenue, P.O. Box 9086, Addis Ababa</wicri:regionArea><wicri:noRegion>Addis Ababa</wicri:noRegion></affiliation></author><author><name sortKey="Asrat, Daniel" sort="Asrat, Daniel" uniqKey="Asrat D" first="Daniel" last="Asrat">Daniel Asrat</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1250 5688</institution-id><institution-id institution-id-type="GRID">grid.7123.7</institution-id><institution>Department of Microbiology,</institution><institution>Immunology & Parasitology, School of Medicine, College of Health Sciences, Addis Ababa University,</institution></institution-wrap>Churchill Avenue, P.O. Box 9086, Addis Ababa, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Churchill Avenue, P.O. Box 9086, Addis Ababa</wicri:regionArea><wicri:noRegion>Addis Ababa</wicri:noRegion></affiliation></author></analytic><series><title level="j">Infectious Agents and Cancer</title><idno type="eISSN">1750-9378</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">In recent years, saprophytic bacteria have been emerging as potential human pathogens causing life-threatening infections in patients with malignancies. However, evidence is lacking concerning such bacteria, particularly in sub-Saharan countries. This study was designed to determine the spectrum and drug resistance profile of the rare bacterial pathogens causing bloodstream infections (BSIs) in febrile cancer patients at a referral hospital in Ethiopia.</p></sec><sec><title>Methods</title><p id="Par2">Between December 2011 and June 2012, blood samples were collected from 107 patients with cancer in Tikur Anbessa hospital. Culturing was performed using the blood culture bottles and solid media and the microorganisms were identified using the gram staining and APINE identification kits (Biomerieux, France). The disk diffusion method was used for the antimicrobial susceptibility testing.</p></sec><sec><title>Results</title><p id="Par3">Overall, 13 (12.2%) rare human pathogens were isolated from 107 adult febrile cancer patients investigated. <italic>Aeromonas hydrophilia</italic> species (a fermentative gram-negative rod) was the predominant isolate, 30.8% (4/13), followed by <italic>Chryseomonas luteola</italic> 15.4% (2/13), <italic>Sphignomonas poucimobilis</italic> 15.4% (2/13), <italic>and Pseudomonas fluorescens</italic> 15.4% (2/13). Of the nine isolates tested for a nine set of antibiotics, 89% were resistant to amoxicillin-clavulanic acid, ampicillin, and trimethoprim-sulphamethoxazole.</p></sec><sec><title>Conclusions</title><p id="Par4">This study revealed the emergence of saprophytic bacteria as potential drug-resistant nosocomial pathogens in Ethiopian patients with cancer. As these pathogens are ubiquitous in the environment, infection prevention actions should be strengthened in the hospital and early diagnosis and treatment with appropriate antibiotics are warranted for those already infected.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Walshe, Lj" uniqKey="Walshe L">LJ Walshe</name></author><author><name sortKey="Malak, Sf" uniqKey="Malak S">SF Malak</name></author><author><name sortKey="Eagan, J" uniqKey="Eagan J">J Eagan</name></author><author><name sortKey="Sepkowitz, Ka" uniqKey="Sepkowitz K">KA Sepkowitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wisplinghoff, H" uniqKey="Wisplinghoff H">H Wisplinghoff</name></author><author><name sortKey="Bischoff, T" uniqKey="Bischoff T">T Bischoff</name></author><author><name sortKey="Tallent, Sm" uniqKey="Tallent S">SM Tallent</name></author><author><name sortKey="Seifert, H" uniqKey="Seifert H">H 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Calandra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bloch, Kc" uniqKey="Bloch K">KC Bloch</name></author><author><name sortKey="Nadarajah, R" uniqKey="Nadarajah R">R Nadarajah</name></author><author><name sortKey="Jacobs, R" uniqKey="Jacobs R">R Jacobs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gungor, S" uniqKey="Gungor S">S Güngör</name></author><author><name sortKey="Ozen, M" uniqKey="Ozen M">M Özen</name></author><author><name sortKey="Akinci, A" uniqKey="Akinci A">A Akinci</name></author><author><name sortKey="Durmaz, R" uniqKey="Durmaz R">R Durmaz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vandamme, P" uniqKey="Vandamme P">P Vandamme</name></author><author><name sortKey="Bernardet, J F" uniqKey="Bernardet J">J-F Bernardet</name></author><author><name sortKey="Segers, P" uniqKey="Segers P">P Segers</name></author><author><name sortKey="Kersters, K" 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sortKey="Schroyens, W" uniqKey="Schroyens W">W Schroyens</name></author><author><name sortKey="Gadisseur, A" uniqKey="Gadisseur A">A Gadisseur</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andersson, A" uniqKey="Andersson A">A Andersson</name></author><author><name sortKey="Weiss, N" uniqKey="Weiss N">N Weiss</name></author><author><name sortKey="Rainey, F" uniqKey="Rainey F">F Rainey</name></author><author><name sortKey="Salkinoja Salonen, M" uniqKey="Salkinoja Salonen M">M Salkinoja-Salonen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anahory, T" uniqKey="Anahory T">T Anahory</name></author><author><name sortKey="Darbas, H" uniqKey="Darbas H">H Darbas</name></author><author><name sortKey="Ongaro, O" uniqKey="Ongaro O">O Ongaro</name></author><author><name sortKey="Jean Pierre, H" uniqKey="Jean Pierre H">H Jean-Pierre</name></author><author><name sortKey="Mion, P" uniqKey="Mion P">P Mion</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Darbas, H" uniqKey="Darbas H">H Darbas</name></author><author><name sortKey="Jean Pierre, H" uniqKey="Jean Pierre H">H Jean-Pierre</name></author><author><name sortKey="Paillisson, J" uniqKey="Paillisson J">J Paillisson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gill, V" uniqKey="Gill V">V Gill</name></author><author><name sortKey="Farmer, J" uniqKey="Farmer J">J Farmer</name></author><author><name sortKey="Grimont, P" uniqKey="Grimont P">P Grimont</name></author><author><name sortKey="Asbury, M" uniqKey="Asbury M">M Asbury</name></author><author><name sortKey="Mcintosh, C" uniqKey="Mcintosh C">C McIntosh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, V" uniqKey="Wong V">V Wong</name></author><author><name sortKey="Levi, K" uniqKey="Levi K">K Levi</name></author><author><name sortKey="Baddal, B" uniqKey="Baddal B">B Baddal</name></author><author><name sortKey="Turton, J" uniqKey="Turton J">J Turton</name></author><author><name sortKey="Boswell, Tc" uniqKey="Boswell T">TC Boswell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moody, Mr" uniqKey="Moody M">MR Moody</name></author><author><name sortKey="Young, Vm" uniqKey="Young V">VM Young</name></author><author><name sortKey="Kenton, Dm" uniqKey="Kenton D">DM Kenton</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Éthiopie</li></country></list><tree><country name="Éthiopie"><noRegion><name sortKey="Arega, Balew" sort="Arega, Balew" uniqKey="Arega B" first="Balew" last="Arega">Balew Arega</name></noRegion><name sortKey="Abubeker, Abdulaziz" sort="Abubeker, Abdulaziz" uniqKey="Abubeker A" first="Abdulaziz" last="Abubeker">Abdulaziz Abubeker</name><name sortKey="Adane, Kelemework" sort="Adane, Kelemework" uniqKey="Adane K" first="Kelemework" last="Adane">Kelemework Adane</name><name sortKey="Arega, Balew" sort="Arega, Balew" uniqKey="Arega B" first="Balew" last="Arega">Balew Arega</name><name sortKey="Asrat, Daniel" sort="Asrat, Daniel" uniqKey="Asrat D" first="Daniel" last="Asrat">Daniel Asrat</name><name sortKey="Belay, Ezra" sort="Belay, Ezra" uniqKey="Belay E" first="Ezra" last="Belay">Ezra Belay</name><name sortKey="Wolde Amanuel, Yimtubezinash" sort="Wolde Amanuel, Yimtubezinash" uniqKey="Wolde Amanuel Y" first="Yimtubezinash" last="Wolde-Amanuel">Yimtubezinash Wolde-Amanuel</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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